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 Nexium (esomeprazole): What is Nexium esomeprazole used for? Esomeprazole is a proton pump inhibitor that is used to treat certain digestive disorders such as gastroesophageal reflux disease (GERD) and erosive esophagitis. It works by reducing the production of stomach acid, which can help to relieve symptoms such as heartburn, difficulty swallowing, and persistent cough. Esomeprazole is available in the form of a capsule and is usually taken once a day, either in the morning or evening, with or without food. It may take several days for the full effect of the medication to be felt. It is important to take esomeprazole exactly as prescribed by your healthcare provider. Do not take more or less of the medication or take it for a longer period of time than directed. Some common uses include; Treating and preventing stomach and intestine ulcers Reflux esophagitis treatment and prevention (damage to the oesophagus from stomach acid) lowering the risk of gastrointestinal bleeding in nonste